Monthly Archives: February 2017

Paper by Julian Hassinger now published in PNAS

Congratulations to Julian Hassinger on his paper “Design principles for robust vesiculation in clathrin-mediated endocytosis” now published in the Proceedings of the National Academy of Sciences.

Design principles for robust vesiculation. The rigidity of the plasma membrane, as well as the membrane tension, resists budding by curvature-generating coats. In the low tension regime, as defined by the vesiculation number, increasing the coat area or spontaneous curvature is sufficient to induce a smooth evolution from a flat membrane to a closed bud. A combination of increased coat rigidity and force from actin polymerization is necessary to ensure robust vesiculation in the high membrane-tension regime.