Congratulations to Yidi, her former undergraduate Tommy, Joh, Charlotte, and collaborators in the Xu Lab and Pollard Lab on their new paper “Direct comparison of clathrin-mediated endocytosis in budding and fission yeast reveals conserved and evolvable features” now published at eLife!

Comparison of endocytic vesicle formation in fission and budding yeast. Timeline and summary of the average molecule numbers for indicated coat proteins and actin machinery components in fission (A) and budding yeast (B) endocytosis. Scission occurs at the time 0. Steps (I) through (V) represent the full process from membrane invagination initiation to vesicle scission. See text (last section in Discussion) for detailed key similarities and differences in fission yeast and budding yeast in terms of protein numbers, architecture and function of the endocytic coat and associated actin machinery.

Congratulations to our collaborators in the Cui Lab and Matt Akamatsu on their paper “Membrane curvature underlies actin reorganization in response to nanoscale surface topography” now published in PNAS.

Vertical nanostructure-induced actin polymerization is curvature dependent.

Congratulations to Daphne and collaborators in the Hockemeyer Lab whose work on genome-edited, stem-cell derived organoids is featured in a new paper in Science on imaging using lattice light sheet with adaptive optics.

Adaptive optical lattice light-sheet microscopy (AO-LLSM).

Congratulations to Yidi, her former and current undergraduates Niki and Tommy, and collaborators in the Darzacq Lab, on their new paper “Switch-like Arp2/3 activation upon WASP and WIP recruitment to an apparent threshold level by multivalent linker proteins in vivo” now published at eLife!

Switch-like activation of the Arp2/3 complex mediated by SH3 domain-PRM mediated interactions during yeast CME.

Congratulations to our collaborators in the Cui Lab, Matt Akamatsu, and former lab members Jessica Marks and Alex Grassart on their paper “Nanoscale manipulation of membrane curvature for probing endocytosis in live cells” now published in Nature Nanotechnology.

Vertical nanopillars generate well-defined membrane curvatures that induce local accumulation of endocytic proteins.